LTBR cDNA ORF Clone, Human, C-Myc tag General Information
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 516 A>C not causing the amino acid variation.
Full length Clone DNA of Human lymphotoxin beta receptor (TNFR superfamily, member 3) with C terminal Myc tag.
Enhanced CMV promoter
HindIII + XbaI (6kb + 1.36kb)
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
LTBR cDNA ORF Clone, Human, C-Myc tag Validated Images
LTBR cDNA ORF Clone, Human, C-Myc tag Alternative Names
CD18 cDNA ORF Clone, Human;D12S370 cDNA ORF Clone, Human;LT-BETA-R cDNA ORF Clone, Human;TNF-R-III cDNA ORF Clone, Human;TNFCR cDNA ORF Clone, Human;TNFR-RP cDNA ORF Clone, Human;TNFR2-RP cDNA ORF Clone, Human;TNFR3 cDNA ORF Clone, Human;TNFRSF3 cDNA ORF Clone, Human
LTBR Background Information
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.
lymphotoxin beta receptor (TNFR superfamily, member 3)
Summers deLuca L, et al. (2011) A LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells. Proc Natl Acad Sci. 108(5):2046-51.Bista P, et al. (2010) TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem. 285(17):12971-8.Xu Y, et al. (2011) Adiponectin inhibits lymphotoxin-β receptor-mediated NF-κB signaling in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 404(4):1060-4.