SOCS3 cDNA ORF Clone, Human, C-HA tag General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human suppressor of cytokine signaling 3 with C terminal HA tag.
Enhanced CMV promoter
KpnI + XbaI (6kb + 0.72kb)
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
SOCS3 cDNA ORF Clone, Human, C-HA tag Validated Images
SOCS3 cDNA ORF Clone, Human, C-HA tag Alternative Names
ATOD4 cDNA ORF Clone, Human;CIS3 cDNA ORF Clone, Human;Cish3 cDNA ORF Clone, Human;SOCS-3 cDNA ORF Clone, Human;SSI-3 cDNA ORF Clone, Human;SSI3 cDNA ORF Clone, Human
SOCS3 Background Information
Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 / CIS3 is involved in negative regulation of cytokines that signal through the JAK / STAT pathway. SOCS3 / CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 / CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 / CIS3 regulates IL-6 signaling. SOCS3 / CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 / CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.
suppressor of cytokine signaling 3
Hoertner M., et al., 2002, Eur. J. Biochem. 269:2516-26. Yamamoto K., et al., 2003, Biochem. Biophys. Res. Commun. 310 : 1188-93. Kamura T., et al., 2004, Genes Dev. 18:3055-65. Okamura A., et al., 2004, Blood 103:2997-3004. Ekelund E., et al., 2006, Am. J. Hum. Genet. 78:1060-5.