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휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA 태그

데이터시트리뷰관련제품프로토콜
Human ATL1 cDNA 클론 제품 정보
Gene_bank_ref_id:NM_015915.4
cDNA 크기:1677bp
cDNA 설명:Full length Clone DNA of Homo sapiens atlastin GTPase 1 , transcript variant 1 with N terminal HA tag.
유전자 동의어:FSP1, GBP3, SPG3, SPG3A, AD-FSP, atlastin1
:Human
벡터:pCMV3-N-HA
Plasmid:
제한 사이트:
태그 씨퀀스:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
염기서열 설명:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
보관:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA 태그 on other vectors
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark 태그HG10523-ACG288840
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark 태그HG10523-ACR288840
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark 태그HG10523-ANG288840
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-OFPSpark 태그HG10523-ANR288840
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag 태그HG10523-CF253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His 태그HG10523-CH253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc 태그HG10523-CM253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA 태그HG10523-CY253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone in cloning vectorHG10523-M88420
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag 태그HG10523-M-F253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag 태그HG10523-NF253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His 태그HG10523-NH253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc 태그HG10523-NM253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA 태그HG10523-NY253470
휴먼 SPG3A/ATL1 transcript variant 1 Gene ORF cDNA clone expression plasmidHG10523-UT253470
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연구배경

Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to the GBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 50-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. ATL1 / SPG3A is also expressed in upper and lower motor neurons (at protein level). A distinguishing feature of ATL1 / SPG3A is its frequent early onset, raising the possibility that developmental abnormalities may be involved in its pathogenesis. Missense SPG3A mutant atlastin-1 proteins have impaired GTPase activity and may act in a dominant-negative, loss-of-function manner by forming mixed oligomers with wild-type atlastin-1. Defects in ATL1 / SPG3A are the cause of spastic paraplegia autosomal dominant type 3 (SPG3), also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

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Cat No: HG10523-NY
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재고정보2-3 weeks
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