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휴먼 TDO2 qPCR primer pairs

    데이터시트리뷰관련제품프로토콜
    휴먼 TDO2 qPCR Product Information
    Gene_bank_ref_id:
    유전자 동의어:TDO, TPH2, TRPO, TDO2
    Pcr_사이즈(bp):
    QPCR Primer Description:Verified forward and reverse primers for analyzing the quantitative expression of gene
    품질 관리:The primer mix has been verified to generate satisfactory qPCR data on Roche LightCycler480
    Shipping_carrier:1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions) is shipped at ambiente temperatura.
    보관:The lyophilized product is stable for one year from date of receipt when stored at -20℃.
    The suspended product is stable for six months from date of receipt when stored at -20℃.
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    Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.

    Unique Primer Design

    To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.

    Strict Validation Process

    Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.

    Uniform PCR conditions, Saving time and cost

    ~100% amplification curve, ensuring the accuracy of the RNA quantitative

    TDO2 연구배경

    TDO2 gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    휴먼 TDO2 참고자료
  • Wu W, Nicolazzo JA, Wen L, et al. Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer’s Disease Brain. Adlard PA, ed. PLoS ONE. 2013;8(4):e59749.
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    Cat No: HP101786
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