LIGHT qPCR Primer Pairs, Human

Cat: HP100420
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LIGHT qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
LIGHT qPCR Primer Pairs, Human Alternative Names
CD258 qPCR Primer Pairs, Human;HVEML qPCR Primer Pairs, Human;LIGHT qPCR Primer Pairs, Human;LTg qPCR Primer Pairs, Human;TR2 qPCR Primer Pairs, Human
LIGHT Background Information

LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble nonsignaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+ and CD8+ T cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.

Immune Checkpoint
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor (ligand) superfamily, member 14
Research Areas
References
  • Ogawa T, et al. (2010) CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis. J Urol. 183(3): 1206-12.
  • Kanodia S, et al. (2010) Expression of LIGHT/TNFSF14 combined with vaccination against human papillomavirus Type 16 E7 induces significant tumor regression. Cancer Res. 70(10): 3955-64.
  • Hosokawa Y, et al. (2010) TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts. Mol Immunol. 47(4): 666-70.
  • LIGHT qPCR Primer Pairs, Cynomolgus, Related Products

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    LIGHT cDNA ORF Clone, Cynomolgus, C-His tag CG90090-CH
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    LIGHT cDNA ORF Clone, Cynomolgus, C-Myc tag CG90090-CM
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    LIGHT qPCR Primer Pairs, Rat, Related Products

    Product Name Catalog#(PDF)
    LIGHT cDNA ORF Clone in Cloning Vector, Rat RG80175-G
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    LIGHT cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80175-NF
    LIGHT cDNA ORF Clone, Rat, C-His tag RG80175-CH
    LIGHT cDNA ORF Clone, Rat, N-His tag RG80175-NH
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    LIGHT qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
    LIGHT cDNA ORF Clone in Cloning Vector, Mouse MG50980-G
    LIGHT cDNA ORF Clone, Mouse, untagged MG50980-UT
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    LIGHT cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50980-ACG
    LIGHT cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50980-ACR
    LIGHT cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50980-CF
    LIGHT cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50980-NF
    LIGHT cDNA ORF Clone, Mouse, C-His tag MG50980-CH
    LIGHT cDNA ORF Clone, Mouse, N-His tag MG50980-NH
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    LIGHT qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    LIGHT cDNA ORF Clone in Cloning Vector, Human HG10386-M
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    LIGHT cDNA ORF Clone, Human, C-GFPSpark® tag HG10386-ACG
    LIGHT cDNA ORF Clone, Human, N-GFPSpark® tag HG10386-ANG
    LIGHT cDNA ORF Clone, Human, C-OFPSpark® tag HG10386-ACR
    LIGHT cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10386-CF
    LIGHT cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10386-NF
    LIGHT cDNA ORF Clone, Human, C-His tag HG10386-CH
    LIGHT cDNA ORF Clone, Human, N-His tag HG10386-NH
    LIGHT cDNA ORF Clone, Human, C-HA tag HG10386-CY
    LIGHT cDNA ORF Clone, Human, N-HA tag HG10386-NY
    LIGHT cDNA ORF Clone, Human, C-Myc tag HG10386-CM
    LIGHT cDNA ORF Clone, Human, N-Myc tag HG10386-NM
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