Interferon beta/IFN-beta/IFNB1  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: CHO Stable Cells  
10704-HNAS-500
10704-HNAS-5
10704-HNAS-20
10704-HNAS-100
10704-HNAS-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
제품 설명: Active  
발현 숙주: Human Cells  
10704-H02H-5
10704-H02H-20
10704-H02H-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
제품 설명: Active  
발현 숙주: Human Cells  
50708-MCCH-5
50708-MCCH-20
50708-MCCH-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
제품 설명: Active  
발현 숙주: Human Cells  
50708-M02H-5
50708-M02H-20
50708-M02H-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

Interferon beta/IFN-beta/IFNB1 Related Area

Interferon beta/IFN-beta/IFNB1 관련 경로

    Interferon beta/IFN-beta/IFNB1 관련 제품

    Interferon beta/IFN-beta/IFNB1 요약 및 단백질 정보

    Interferon beta/IFN-beta/IFNB1 배경

    하부단위 구조: Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.
    세포하 위치: Secreted.
    염기서열 유사성: Belongs to the alpha/beta interferon family. {ECO:0000305}.
    General information above from UniProt

    Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferon-beta (IFN beta) is an extra-cellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or cause autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis, and thus has therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of a chronic progressive CNS inflammation.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Interferon beta/IFN-beta/IFNB1 대체 이름

    Interferon beta,IFB,IFF, []
    IFB,IFF,IFNB, [homo-sapiens]
    IFN beta,IFNB, [human]
    Ifb,IFN beta,IFNB,Ifnb1,RP23-19G2.2, [mouse]
    Ifb,IFNB,IFN-beta, [mus-musculus]

    Interferon beta/IFN-beta/IFNB1 관련 연구

  • Kohriyama T, et al. (2008) Interferon-beta treatment for multiple sclerosis and predictors of response. Nippon Rinsho. 66(6): 1119-26.
  • Stbgen JP. (2009) Recombinant interferon-beta therapy and neuromuscular disorders. J Neuroimmunol. 212(1-2): 132-41.
  • Abraham AK, et al. (2009) Mechanisms of interferon-beta effects on bone homeostasis. Biochem Pharmacol. 77(12): 1757-62.
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