IL13/IL-13  Protein, Antibody, ELISA Kit, cDNA Clone

제품 설명: Active  
발현 숙주: Human Cells  
10369-H01H-20
10369-H01H-10
20 µg 
10 µg 
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발현 숙주: CHO Stable Cells  
10369-HNAC-500
10369-HNAC-5
10369-HNAC-20
10369-HNAC-100
10369-HNAC-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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발현 숙주: Human Cells  
50225-MNAH-20
50225-MNAH-100
20 µg 
100 µg 
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발현 숙주: Human Cells  
11057-CNAH-500
11057-CNAH-5
11057-CNAH-20
11057-CNAH-100
11057-CNAH-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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발현 숙주: Human Cells  
11057-C07H-5
11057-C07H-20
11057-C07H-100
5 µg 
20 µg 
100 µg 
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  • Slide 1

IL13/IL-13 Related Area

IL13/IL-13 관련 경로

    IL13/IL-13 관련 제품

    IL13/IL-13 요약 및 단백질 정보

    IL13/IL-13 배경

    유전자 요약: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
    General information above from NCBI
    하부단위 구조: Interacts with IL13RA2. {ECO:0000269|PubMed:20223216}.
    세포하 위치: Secreted.
    질병과의 관련성: DISEASE: Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    염기서열 유사성: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
    General information above from UniProt

    Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    IL13/IL-13 대체 이름

    IL13/IL-13 관련 연구

  • Junttila IS, et al. (2008) Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 205(11): 2595-608.
  • Shimamura T,et al. (2008) Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J Immunol. 181(7): 4656-65.
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