IL-17R / IL-17RA (CD217) 항체, 생쥐 단클론항체

    데이터시트리뷰관련제품프로토콜
     IL17RA 항체 제품 정보
    면역원:Recombinant Rat IL-17R / IL-17RA (CD217) protein (Catalog#80190-R08H)
    Clone ID:05
    면역글로불린(Ig) 유형:Mouse IgG1
    농도:
    내독소:
    Formulation:0.2 μm filtered solution in PBS
    제조방법:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IL-17R / IL-17RA (CD217) (rh IL-17R / IL-17RA (CD217); Catalog#80190-R08H; NP_001101353.2; Met1-Pro320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity.
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                IL17RA/IL-17RA/CD217 연구배경

                Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

                 IL17RA/IL-17RA/CD217 참고자료
              • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
              • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
              • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
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                Cat No: 80190-MM05-100
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                Datasheet & Documentation

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