Anti-IL17RA Antibody

All IL17RA Reagents

Anti-IL17RA Antibody (Mouse Monoclonal antibody) General Information

Product name

Anti-IL17RA Antibody

Validated applications

ELISA

Species reactivity

Reacts with: Rat

Specificity

Rat IL17RA
No cross-reactivity in ELISA with Human IL17RA Mouse IL17RA Human IL17RD Human cell lysate (293 cell line)

Immunogen

Recombinant Rat IL-17R / IL-17RA （CD217） protein (Catalog#80190-R08H)

Preparation

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IL-17R / IL-17RA （CD217） (Catalog#80190-R08H; NP_001101353.2; Met1-Pro320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity.

Source

Monoclonal Mouse IgG1 Clone #05

Purification

Protein A

Formulation

0.2 μm filtered solution in PBS

Conjugate

Unconjugated

Form

Liquid

Shipping

This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-IL17RA Antibody (Mouse Monoclonal antibody) Validated Applications

Application	Dilution	Notes
ELISA	1:1000-1:2000

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

IL17RA Background Information

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Full Name

interleukin 17 receptor A

Research Areas

References

Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.

Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.

Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.

Product Description	Host	Clonality	Application	Catalog# (PDF)
Anti-IL17RA Antibody	Rabbit	Polyclonal	ELISA	80190-RP01
Anti-IL17RA Antibody	Rabbit	Polyclonal	ELISA	80190-T16
Anti-IL17RA Antibody	Rabbit	Polyclonal	ELISA	50328-RP02
Anti-IL17RA Antibody	Rabbit	Monoclonal	ELISA	10895-R012
Anti-IL17RA Antibody	Rabbit	Polyclonal	ELISA	10895-T16
Anti-IL17RA Antibody	Mouse	Monoclonal	ELISA,FCM	10895-MM06
Anti-IL17RA Antibody	Rabbit	Polyclonal	ELISA	10895-RP01
Anti-IL17RA Antibody (PE)	Mouse	Monoclonal	FCM	10895-MM06-P
Anti-IL17RA Antibody	Rabbit	Monoclonal	FCM,Neutralization	10895-R004
Anti-IL17RA Antibody (FITC)	Mouse	Monoclonal	FCM	10895-MM06-F
Anti-IL17RA Antibody (FITC)	Rabbit	Monoclonal	FCM	10895-R004-F
Anti-IL17RA Antibody (APC)	Mouse	Monoclonal	FCM	10895-MM06-A
Anti-IL17RA Antibody	Mouse	Monoclonal	WB	10895-MM07

Documents
Datasheet Download
MSDS Download
Protocol Download
You Recently Viewed

Contact us:

All IL17RA Reagents

CRO Services

Product recommended