IL-18: IL-18 Protein | IL-18 Antibody

IL-18 Gene family

IL-18 Background

Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

Reference for IL-18

  • Dinarello CA. (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 103: 11-24.
  • Takeda K, et al.. (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8(3): 383-90.
  • Gracie JA, et al.. (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104(10): 1393-401.

IL-18 Protein

IL-18 protein function

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000305}.

IL-18 protein expression


In macrophages, release is increased by endocannabinoid anandamide/AEA.

IL-18 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

IL-18 Antibody

There are 11 IL-18 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), WB, IP, ELISA(Det). There are 9 IL-18 antibody for ELISA, 2 IL-18 antibody for ELISA(Cap), 2 IL-18 antibody for WB, 2 IL-18 antibody for IP, 1 IL-18 antibody for ELISA(Det). Among all these IL-18 antibodies, there are 3 anti-IL-18 mouse monoclonal antibodies , 3 anti-IL-18 rabbit monoclonal antibodies , 5 anti-IL-18 rabbit polyclonal antibodies . All the IL-18 anbodies are produced in house and all are in stock. IL-18 antibody customerized service is available.

IL-18 Gene

IL18 gene / cDNA is a protein-coding gene which located on 11q23.1. The IL18 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.190 organisms have orthologs with human gene IL18.