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IL-36B / IL-1F8 항체, 토끼 다클론 항체, Antigen Affinity Purified

데이터시트리뷰관련제품프로토콜
Mouse IL36B 항체 제품 정보
면역원:Recombinant Mouse IL-36B / IL-1F8 protein (Catalog#51071-MNAE)
Clone ID:
면역글로불린(Ig) 유형:Rabbit IgG
농도:
내독소:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
제조방법:Produced in rabbits immunized with purified, recombinant Mouse IL-36B / IL-1F8 (rM IL-36B / IL-1F8; Catalog#51071-MNAE; Q9D6Z6; Met1-Lys183). IL-36B / IL-1F8 specific IgG was purified by Mouse IL-36B / IL-1F8 affinity chromatography.
Mouse IL36B 항체 사용 가이드
특이성:Mouse IL-36B / IL-1F8
적용:WB, ELISA, IHC-P

WB: 5-10 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL-36B / IL-1F8. The detection limit for Mouse IL-36B / IL-1F8 is approximately 0.039 ng/well.

IHC-P: 0.1-2 μg/mL

보관:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse IL36B Antibody WB Application Image
Mouse IL36B Antibody IHC Application Image
IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[이미지를 확대하려면 클릭]
Caption:
Immunochemical staining of mouse IL1F8 in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
IL-36B / IL-1F8 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[이미지를 확대하려면 클릭]
Caption:
Immunochemical staining of mouse IL1F8 in mouse stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other IL36B Antibody Products
IL36B/IL1F8 연구배경

Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.

Mouse IL36B/IL1F8 참고자료
  • Magne D, et al. (2006) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Research & Therapy. 8: R80.
  • Smith DE, et al. (2000) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. The Journal of Biological Chemistry. 275: 1169-75.
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    Cat No: 51071-RP02-200
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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