IL12B/IL-12B  Protein, Antibody, ELISA Kit, cDNA Clone

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10052-H02H-20
10052-H02H-10
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제품 설명: Active  
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10052-H08H-500
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10052-H08H-20
10052-H08H-100
10052-H08H-1
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51004-M02H-50
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발현 숙주: Human Cells  
51004-M08H-50
51004-M08H-20
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발현 숙주: Human Cells  
51004-MCCH-50
51004-MCCH-20
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발현 숙주: Human Cells  
80352-R02H-20
80352-R02H-10
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발현 숙주: Human Cells  
80352-R08H-20
80352-R08H-10
20 µg 
10 µg 
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65008-T08H-5
65008-T08H-20
65008-T08H-100
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IL12B/IL-12B Related Area

IL12B/IL-12B 관련 경로

    IL12B/IL-12B 관련 제품

    IL12B/IL-12B 요약 및 단백질 정보

    IL12B/IL-12B 배경

    유전자 요약: IL12B gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by IL12B gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL12B gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL12B gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    하부단위 구조: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. {ECO:0000269|PubMed:10899108, ECO:0000269|PubMed:18680750, ECO:0000269|PubMed:18708069, ECO:0000269|PubMed:7836910}.
    세포하 위치: Secreted.
    번역 후: Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
    질병과의 관련성: DISEASE: Immunodeficiency 29 (IMD29) [MIM:614890]: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD29 is characterized by undetectable IL12B secretion from leukocytes. Affected individuals generally present with BCG disease after vaccination in childhood, and at least half also have Salmonella infection. Disease phenotype is relatively mild, and patients have a good prognosis. {ECO:0000269|PubMed:11753820, ECO:0000269|PubMed:9854038}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Psoriasis 11 (PSORS11) [MIM:612599]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    염기서열 유사성: Belongs to the type I cytokine receptor family. Type 3 subfamily. {ECO:0000305}.; Contains 1 fibronectin type-III domain. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    IL12B/IL-12B 대체 이름

    IMD28,CLMF,NKSF,CLMF2,IMD29,NKSF2,IL-12B, [homo-sapiens]
    CLMF,CLMF2,IL12B,IL-12B,NKSF,NKSF2, [human]
    Il12b,Il-12b,Il12p40,Il-12p40,RP23-388G23.1,P40, [mouse]
    p40,Il-12b,Il12p40,Il-12p40, [mus-musculus]

    IL12B/IL-12B 관련 연구

  • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
  • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
  • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.
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