IL17A/IL-17A/IL17  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Yeast  
12047-H07Y-50
12047-H07Y-100
50 µg 
100 µg 
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  • Slide 1
발현 숙주: E. coli  
12047-HNAE-5
12047-HNAE-20
12047-HNAE-100
5 µg 
20 µg 
100 µg 
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  • Slide 1
발현 숙주: Baculovirus-Insect Cells  
12047-H07B-50
12047-H07B-5
12047-H07B-20
12047-H07B-100
50 µg 
5 µg 
20 µg 
100 µg 
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  • Slide 1
발현 숙주: CHO Stable Cells  
12047-HNAS-500
12047-HNAS-5
12047-HNAS-20
12047-HNAS-100
12047-HNAS-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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  • Slide 1
제품 설명: Active  
발현 숙주: E. coli  
51065-MNAE-50
51065-MNAE-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
발현 숙주: E. coli  
70102-DNAE-50
70102-DNAE-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Baculovirus-Insect Cells  
90306-KNAB-20
90306-KNAB-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
제품 설명:   
발현 숙주: Baculovirus-Insect Cells  
65006-T07B-5
65006-T07B-20
65006-T07B-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

IL17A/IL-17A/IL17 Related Area

IL17A/IL-17A/IL17 관련 제품

IL17A/IL-17A/IL17 요약 및 단백질 정보

IL17A/IL-17A/IL17 배경

유전자 요약: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis
General information above from NCBI
하부단위 구조: Homodimer. {ECO:0000269|PubMed:19835883}.
세포하 위치: Secreted.
조직 특이성: Restricted to activated memory T-cells.
번역 후: Found both in glycosylated and nonglycosylated forms.
염기서열 유사성: Belongs to the IL-17 family. {ECO:0000305}.
General information above from UniProt

IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL17A/IL-17A/IL17 대체 이름

IL17,CTLA8,IL-17,IL-17A, [homo-sapiens]
CTLA8,CTLA-8,cytotoxic T-lymphocyte-associated antigen 8,cytotoxic T-lymphocyte-associated protein 8,cytotoxic T-lymphocyte-associated serine esterase 8,IL17,IL-17,IL-17A,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8),interleukin-17A, [human]
Ctla8,Ctla-8,cytotoxic T-lymphocyte-associated antigen 8. interleukin-17A,Il17,IL-17,IL-17A, [mouse]
Il17,Ctla8,IL-17,Ctla-8,IL-17A, [mus-musculus]

IL17A/IL-17A/IL17 관련 연구

  • Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
  • Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
  • Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
  • Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.
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