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인플루엔자 A H5N1 (A/Thailand/1(KAN-1)/2004) 뉴라미니다아제(NA) 단백질 (His 태그), Biotinylated

데이터시트리뷰관련제품프로토콜
H5N1 NA 단백질 제품 정보
동의어:NA
단백질 구조:A DNA sequence encoding the influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) neuraminidase (His36-Ile469), termed as NA, was fused with a N-terminal polyhistidine tag. The expressed protein was biotinylated in vitro.
:H5N1
발현 숙주:Human Cells
양식 및 배송:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
H5N1 NA 단백질 품질 관리 검사
순도:> 65 % as determined by SDS-PAGE
내독소:< 1.0 EU per μg protein as determined by the LAL method.
안정성:Samples are stable for up to twelve months from date of receipt at -70℃
예상된 N 말단(N Terminal):His
분자량:The recombinant NA subunit of influenza A H5N1 (A/Thailand/1(KAN-1)/2004(H5N1)) comprises 433 amino acids and has a predicted molecular mass of 47.6 kDa. It migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS , pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
H5N1 NA 단백질 사용 가이드
보관:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
복원:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
H5N1 NA Protein SDS-PAGE
Influenza A H5N1 (A/Thailand/1(KAN-1)/2004) Neuraminidase / NA Protein (His Tag), Biotinylated

NA 관련 경로

    Other NA Recombinant Protein Products
    Neuraminidase 연구배경

    Neuraminidases are enzymes that cleave sialic acid groups from glycoproteins. Influenza neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell.

    Influenza neuraminidase is composed of four identical subunits arranged in a square. It is normally attached to the virus surface through a long protein stalk. The active sites are in a deep depression on the upper surface. They bind to polysaccharide chains and clip off the sugars at the end. The surface of neuraminidase is decorated with several polysaccharide chains that are similar to the polysaccharide chains that decorate our own cell surface proteins.

    Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

    Influenza antibody and influenza antibodies are very important research tools for influenza diagnosis, influenza vaccine development, and anti-influenza virus therapy development. Monoclonal or polyclonal antibody can be raised with protein based antigen or peptide based antigen. Antibody raised with protein based antigen could have better specificity and/or binding affinity than antibody raised with peptide based antigen, but cost associated with the recombinant protein antigen is usually higher. Anti influenza virus hemagglutinin (HA) monoclonal antibody or polyclonal antibody can be used for ELISA assay, western blotting detection, Immunohistochemistry (IHC), flow cytometry, neutralization assay, hemagglutinin inhibition assay, and early diagnosis of influenza viral infection.

    Sino Biological has developed state-of-the-art monoclonal antibody development technology platforms: mouse monoclonal antibody and rabbit monoclonal antibody. Our rabbit monoclonal antibody platform is one of a kind and offers some unique advantages over mouse monoclonal antibodies, such as high affinity, low cross-reactivity with rabbit polyclonal antibodies.

    H5N1 Neuraminidase 참고자료
  • Sardet C., et al.,(1989), Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter. Cell 56:271-280.
  • Sardet C., et al., (1990), Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD.Science 247:723-726.
  • Tse C.-M., et al.,(1991), Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.EMBO J. 10:1957-1967.
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    Cat No: 40064-V07H-B-10
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    • Influenza A H5N1 (A/Thailand/1(KAN-1)/2004) Neuraminidase / NA Protein (His Tag), Biotinylated
      최근에 조회한 품목
        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".