인플루엔자 뉴라미니다아제/ 인플루엔자 NA 단백질

Sino Biological offers active influenza neuraminidase proteins for research use.

Influenza Neuraminidase (NA) Background

Neuraminidase is a single-pass type II membrane protein which exists as a homotetramer. It specifically catalyzes the hydrolysis removal of terminal sialic acid residues, and thus also called sialidase. Influenza neuraminidase promotes influenza virus release from infected cells and facilitates virus spread within the respiratory tract. At present, there are only three licensed anti-Influenza drugs namely Relenza (Zanamivir - ZMV), Tamiflu (Oseltamivir - OTV) and Amantadine/Rimantadine. The latter targets the M2 ion channel whereas the other compounds target neuraminidase and were designed through structure-based enzyme inhibitor programmes. The neuraminidase inhibitors interfere with the release of progeny influenza virus from infected host cells, thereby halts the spread of infection in the respiratory tract. The neuraminidase inhibitors are effective against all neuraminidase subtypes and, therefore, against all strains of influenza, a key point in epidemic and pandemic preparedness. In addition, The neuraminidase inhibitors are associated with very little toxicity and are far less likely to promote the development of drug-resistant influenza. Because of a broader antiviral spectrum, better tolerance, and less potential for emergence of resistance than is seen with the M2 inhibitors, the neuraminidase inhibitors represent an important advance in the treatment of influenza.

Influenza Neuraminidase (NA) Protein Products

Influenza Neuraminidase Protein (3) H1N1, A/California/04/2009

Products	Source (CLICK for detailed Info. and Price)	Molecule	Description	Cat No
Protein	Influenza Neuraminidase (NA) H1N1, A/California/04/2009	NA	Fc Tag	11058-V01H
Protein	Influenza Neuraminidase (NA) H1N1, A/California/04/2009	NA	His Tag	11058-V07H
Protein	Influenza Neuraminidase (NA) H1N1, A/California/04/2009	NA	-	11058-VNAHC
Protein	Influenza Neuraminidase (NA) H1N1, A/California/04/2009	NA	-	11058-VNAHC

  11058-VNAHC:  The specific activity is > 200,000 pmoles / min / tube ( 600 µl ) as measured under the described conditions. Measured by its ability to cleave a fluorogenic substrate, 2’-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid.

Influenza Neuraminidase Protein (1) H5N1, A/Anhui/1/2005

Products	Source (CLICK for detailed Info. and Price)	Molecule	Description	Cat No
Protein	Influenza Neuraminidase (NA) H5N1	NA	-	11676-VNAHC
Protein	Influenza Neuraminidase (NA) H5N1	NA	-	11676-VNAHC

  11676-VNAHC:  The specific activity is > 30,000 pmoles / min / tube ( 600 µl ) as measured under the described conditions. Measured by its ability to cleave a fluorogenic substrate, 2’-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid.

  11676-VNAHC:  The specific activity is > 90,000 pmoles / min / tube ( 1.5 ml ) as measured under the described conditions Measured by its ability to cleave a fluorogenic substrate, 2’-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid.

Related Influenza Research Tools

Influenza Hemagglutinin & Antibody Index Page (152)
Influenza Neuraminidase & Antibody (5)
Influenza Hemagglutinin Proteins (117)
Influenza Neuraminidase Proteins (4)
H1N1 Neuraminidase (H1N1 NA) (3)	H5N1 Neuraminidase (H5N1 NA) (1)
H1N1 Neucleoproteins (H1N1 NP) (1)
Influenza Antibodies (37)	Influenza ELISA Kits (3)

Related Links:

• Influenza hemagglutinin (HA) General Information
• Influenza Hemagglutinin (HA) Protein Structure
• Influenza Hemagglutinin (HA) Protein Function