LAG3/LAG-3/CD223  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Human Cells  
  • Slide 1
16498-H05H-200
16498-H05H-50
200 µg 
50 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
16498-H08H-200
16498-H08H-50
200 µg 
50 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
16498-H02H-50
16498-H02H-200
50 µg 
200 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
53069-M08H3-50
53069-M08H3-200
50 µg 
200 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
53069-M02H-200
53069-M02H-50
200 µg 
50 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
53069-M08H-50
53069-M08H-200
50 µg 
200 µg 
Add to Cart
제품 설명:   
발현 숙주: Human Cells  
  • Slide 1
80367-R08H-50
80367-R08H-100
50 µg 
100 µg 
Add to Cart

LAG3/LAG-3/CD223 관련 경로

LAG3/LAG-3/CD223 요약 및 단백질 정보

LAG3/LAG-3/CD223 배경

세포하 위치: Membrane; Single-pass type I membrane protein.
조직 특이성: On cell surface of activated NK and T- lymphocytes.
염기서열 유사성: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
General information above from UniProt

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

LAG3/LAG-3/CD223 대체 이름

CD223, [homo-sapiens]
lymphocyte-activation gene 3,LAG3,CD223,lymphocyte activation gene 3 protein, [human]
lymphocyte-activation gene 3,Lag3,CD223,LAG-3,Ly66,lymphocyte activation gene 3 protein, [mouse]
Ly66,CD223,LAG-3, [mus-musculus]

LAG3/LAG-3/CD223 관련 연구

  • Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
  • Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
  • Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
  • Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
  • Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".