M-CSF/CSF-1  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Yeast  
11792-H08Y-20
11792-H08Y-10
20 µg 
10 µg 
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  • Slide 1
발현 숙주: Human Cells  
11792-HNAH-20
11792-HNAH-10
20 µg 
10 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
11792-H08H-5
11792-H08H-20
11792-H08H-100
5 µg 
20 µg 
100 µg 
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  • Slide 1
발현 숙주: Human Cells  
11792-H02H-50
11792-H02H-5
11792-H02H-100
11792-H02H-10
50 µg 
5 µg 
100 µg 
10 µg 
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발현 숙주: Human Cells  
11792-H08H1-20
11792-H08H1-10
20 µg 
10 µg 
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발현 숙주: Human Cells  
51112-M08H-5
51112-M08H-20
51112-M08H-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
51112-MNAH-5
51112-MNAH-20
51112-MNAH-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
90029-C08H-50
90029-C08H-10
50 µg 
10 µg 
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  • Slide 1
발현 숙주: Human Cells  
90029-C02H-50
90029-C02H-10
50 µg 
10 µg 
Add to Cart
  • Slide 1

M-CSF/CSF-1 Related Area

M-CSF/CSF-1 관련 경로

    M-CSF/CSF-1 요약 및 단백질 정보

    M-CSF/CSF-1 배경

    유전자 요약: It is a cytokine. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.[1] Four transcript variants encoding three different isoforms have been found for this gene.
    General information above from NCBI
    하부단위 구조: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:3264877, ECO:0000269|PubMed:8422357}.
    세포하 위치: Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}.; Processed macrophage colony-stimulating factor 1: Secreted, extracellular space.
    번역 후: N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated. {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:23234360, ECO:0000269|PubMed:3264877}.
    질병과의 관련성: DISEASE: Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.; DISEASE: Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.

    Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

    M-CSF/CSF-1 대체 이름

    M-CSF/CSF-1 관련 연구

    1. Pandit J. et al., 1992, Science. 258: 1358-62.
    2. Tokai M. et al., 2000, J Bacteriol. 182 (10): 2865-8.
    3. Fan X. et al., 2001, Am J Physiol Endocrinol Metab. 280 (1): E103-11.
    4. Frangogiannis NG. et al., 2003, Am J Physiol Heart Circ Physiol. 285 (2): H483-92.
    5. Cupp JS. et al., 2007, Am J Surg Pathol. 31 (6): 970-6.
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