MBL/MBL-2  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: CHO Stable Cells  
10405-HNAS-50
10405-HNAS-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
50063-M04H-50
50063-M04H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
50063-M07H-50
50063-M07H-200
50 µg 
200 µg 
Add to Cart
  • Slide 1

MBL/MBL-2 Related Area

MBL/MBL-2 관련 경로

MBL/MBL-2 요약 및 단백질 정보

MBL/MBL-2 배경

유전자 요약: Human MBL2 gene is located on chromosome 10q11.2-q21. Mice have two homologous genes, but in human the first of them was lost. A low level expression of an MBL1 pseudogene 1 (MBL1P1) was detected in liver. The pseudogene encodes a truncated 51-amino acid protein that is homologous to the MBLA isoform in rodents and some primates
General information above from NCBI
하부단위 구조: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity. {ECO:0000269|PubMed:16116208, ECO:0000269|PubMed:7634089, ECO:0000269|PubMed:9087411}.
도메인: The coiled-coil domain mediates trimerization.
세포하 위치: Secreted {ECO:0000269|PubMed:7982896}.
조직 특이성: Plasma protein produced mainly in the liver. {ECO:0000269|PubMed:18006063}.
염기서열 유사성: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.; Contains 1 collagen-like domain. {ECO:0000305}.
General information above from UniProt

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

MBL/MBL-2 대체 이름

MBL/MBL-2 관련 연구

  • Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
  • Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
  • Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
  • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
  • Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.
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