MMP-14/MMP14  Protein, Antibody, ELISA Kit, cDNA Clone

MMP-14/MMP14 Related Area

MMP-14/MMP14 관련 경로

    MMP-14/MMP14 요약 및 단백질 정보

    MMP-14/MMP14 배경

    촉매 활성: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
    보조 인자: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000250};; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
    하부단위 구조: Interacts (via C-terminal cytoplasmic tail) with BST2. {ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:9724659}.
    도메인: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    세포하 위치: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
    조직 특이성: Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
    유도: Up-regulated by NANOS1. {ECO:0000269|PubMed:18223680}.
    번역 후: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.; Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
    질병과의 관련성: DISEASE: Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269|PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    염기서열 유사성: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    MMP-14/MMP14 대체 이름

    MMP-14/MMP14 관련 연구

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