MMP-16  Protein, Antibody, ELISA Kit, cDNA Clone

MMP-16 관련 경로

MMP-16 관련 제품

MMP-16 관련 제품

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MMP-16 요약 및 단백질 정보

MMP-16 배경

보조 인자: Binds 1 zinc ion per subunit (By similarity).
Calcium (By similarity).
효소 조절: TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.
하부단위 구조: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
도메인: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
세포하 위치: Isoform Long: Cell membrane; Single-pass type I membrane protein; Extracellular side (Potential). Note=Localized at the cell surface of melanoma cells.
Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.
조직 특이성: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
발생 단계: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
번역 후: The precursor is cleaved by a furin endopeptidase (By similarity).
염기서열 유사성: Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.
General information above from UniProt

MMP-16 대체 이름

MMP-16 관련 연구

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