MMP-8 / MMP8  Protein, Antibody, ELISA Kit, cDNA Clone

제품 설명: Active  
발현 숙주: Human Cells  
10254-HNAH-20
10254-HNAH-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
제품 설명: Active  
발현 숙주: Human Cells  
10254-H08H-20
10254-H08H-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
50493-MNAH-20
50493-MNAH-10
20 µg 
10 µg 
Add to Cart
  • Slide 1
발현 숙주: CHO Stable Cells  
50493-M08S-20
50493-M08S-10
20 µg 
10 µg 
Add to Cart
  • Slide 1

MMP-8 / MMP8 Related Area

MMP-8 / MMP8 관련 경로

    MMP-8 / MMP8 요약 및 단백질 정보

    MMP-8 / MMP8 배경

    유전자 요약: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by MMP8 gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. MMP8 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    촉매 활성: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
    보조 인자: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 3 Ca(2+) ions per subunit.;; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 2 Zn(2+) ions per subunit.;
    효소 조절: ENZYME REGULATION: Cannot be activated without removal of the activation peptide.
    하부단위 구조: Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 (By similarity).
    도메인: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    세포하 위치: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=Stored in intracellular granules.
    조직 특이성: Neutrophils.
    염기서열 유사성: Belongs to the peptidase M10A family. {ECO:0000305}.; Contains 4 hemopexin repeats. {ECO:0000305}.
    General information above from UniProt

    Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. Neutrophil collagenase, also known as Matrix metalloproteinase-8, MMP-8, and CLG1, is a member of the peptidase M10A family. MMP-8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumour may have a protective effect against lymph node metastasis. MMP-8 may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 participates in wound repair by contributing to the resolution of inflammation and open the possibility to develop new strategies for treating wound healing defects.

    MMP-8 / MMP8 대체 이름

    MMP-8 / MMP8 관련 연구

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