IL11 cDNA ORF Clone, Mouse, N-His tag General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Mouse interleukin 11 with N terminal His tag.
Enhanced CMV promoter
KpnI + XbaI(6kb+0.63kb)
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
IL11 cDNA ORF Clone, Mouse, N-His tag Validated Images
IL11 cDNA ORF Clone, Mouse, N-His tag Alternative Names
IL-11 cDNA ORF Clone, Mouse
IL11 Background Information
IL11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.
McKinley D. et al., 1992, Genomics. 13 (3): 814-9. Paul SR. et al., 1990, Proc Natl Acad Sci. 87 (19): 7512-6. Kawashima I. et al., 1991, FEBS Lett. 283 (2): 199-202.