PRSS3 cDNA ORF Clone, Mouse, C-HA tag General Information
Full length Clone DNA of Mouse protease, serine, 3 with C terminal HA tag.
Enhanced CMV promoter
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PRSS3 cDNA ORF Clone, Mouse, C-HA tag Alternative Names
MTG cDNA ORF Clone, Mouse;Tb cDNA ORF Clone, Mouse;Try3 cDNA ORF Clone, Mouse;TRY4 cDNA ORF Clone, Mouse
PRSS3 Background Information
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.
protease, serine 3
Venter JC. et al., 2001, Science 291:1304-51. Marsit,CJ. et al., 2005, Mol Carcinog 44 (2):146-50. Rowen, L. et al., 2005, Mol Biol Evol. 22 (8):1712-20. Rosendahl, J. et al., 2010, Pancreatology. 10 (2-3):243-9