S100A1 cDNA ORF Clone, Mouse, untagged General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Mouse S100 calcium binding protein A1.
Enhanced CMV promoter
KpnI + XbaI(6.1kb+0.29kb)
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
S100A1 cDNA ORF Clone, Mouse, untagged Validated Images
S100A1 cDNA ORF Clone, Mouse, untagged Alternative Names
AI266795 cDNA ORF Clone, Mouse;S100 cDNA ORF Clone, Mouse;S100a cDNA ORF Clone, Mouse
S100A1 Background Information
S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.
S100 calcium binding protein A1
Remppis, A .et al., 1996, Biochim. Biophs. Acta. 1313: 253-257. Most, P. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 13889-13894 Okada, M. et al., 2004, J. Biol. Chem. 279: 4221-4233. Schafer, W.E. et al., 1995, Genomics. 25: 638-643. Landar, A. et al., 1996, Cell. Calcium. 20: 279-285.