VDR qPCR Primer Pairs, Mouse

Cat: MP201059
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VDR qPCR Primer Pairs, Mouse General Information
Target Details
Species:
Mouse
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
VDR qPCR Primer Pairs, Mouse Alternative Names
Nr1i1 qPCR Primer Pairs, Mouse
VDR Background Information

VDR (vitamin D(1,25- dihydroxyvitamin D3)receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors, that form heterodimers with members of the retinoid X receptor family. VDRs repress expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. VDR is expressed in the intestine, thyroid and kidney and has a vital role in calcium homeostasis. It is the nuclear hormone receptor, also called transcription factor that mediates the action of vitamin D3. Inherited mutations in the VDR gene leads to rickets.

Full Name
vitamin D (1,25- dihydroxyvitamin D3) receptor
References
  • Moore DD, et al. (2006) The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol Rev. 58(4):742-59.
  • Szpirer J, et al. (1991)The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7. Genomics. 11(1):168-73.
  • Germain P, et al. (2006) Overview of nomenclature of nuclear receptors. Pharmacol Rev. 58(4): 685-704.
  • Adorini L, et al. (2006) Vitamin D receptor agonists, cancer and the immune system: an intricate relationship. Curr Top Med Chem. 6(12):1297-301.
  • Luderer HF, et al. (2010) The vitamin D receptor, the skin and stem cells. J Steroid Biochem Mol Biol. 121(1-2):314-6.
  • VDR qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
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    VDR qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    VDR cDNA ORF Clone in Cloning Vector, Human HG12025-G
    VDR cDNA ORF Clone, Human, untagged HG12025-UT
    VDR Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG12025-ACGLN
    VDR cDNA ORF Clone, Human, C-GFPSpark® tag HG12025-ACG
    VDR cDNA ORF Clone, Human, N-GFPSpark® tag HG12025-ANG
    VDR cDNA ORF Clone, Human, C-OFPSpark® tag HG12025-ACR
    VDR cDNA ORF Clone, Human, N-OFPSpark® tag HG12025-ANR
    VDR cDNA ORF Clone, Human, C-DDK (Flag®) tag HG12025-CF
    VDR cDNA ORF Clone, Human, N-DDK (Flag®) tag HG12025-NF
    VDR cDNA ORF Clone, Human, C-His tag HG12025-CH
    VDR cDNA ORF Clone, Human, N-His tag HG12025-NH
    VDR cDNA ORF Clone, Human, C-HA tag HG12025-CY
    VDR cDNA ORF Clone, Human, N-HA tag HG12025-NY
    VDR cDNA ORF Clone, Human, C-Myc tag HG12025-CM
    VDR cDNA ORF Clone, Human, N-Myc tag HG12025-NM
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