PCSK9 cDNA ORF Clone in Cloning Vector, Human General Information
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1420 G/A, 2009 G/A resulting in the amino acid Val substitution by Ile, Gly substitution by Glu and 1026 A/G，1380 A/G not causing the amino acid variation.
Full length Clone DNA of Human proprotein convertase subtilisin/kexin type 9.
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PCSK9 cDNA ORF Clone in Cloning Vector, Human Alternative Names
FH3 cDNA ORF Clone, Human;HCHOLA3 cDNA ORF Clone, Human;LDLCQ1 cDNA ORF Clone, Human;NARC-1 cDNA ORF Clone, Human;NARC1 cDNA ORF Clone, Human;PC9 cDNA ORF Clone, Human
PCSK9 Background Information
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
proprotein convertase subtilisin/kexin type 9
Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933. Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498 Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73. Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875. Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.