PD-L1/B7-H1/CD274  Protein, Antibody, ELISA Kit, cDNA Clone

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    PD-L1/B7-H1/CD274 관련 경로

      PD-L1/B7-H1/CD274 요약 및 단백질 정보

      PD-L1/B7-H1/CD274 배경

      하부단위 구조: Interacts with PDCD1.
      세포하 위치: Isoform 1: Cell membrane; Single-pass type I membrane protein.
      Isoform 2: Endomembrane system; Single-pass type I membrane protein.
      조직 특이성: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
      유도: Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up- regulated in B-cells activated by surface Ig cross-linking.
      염기서열 유사성: Belongs to the immunoglobulin superfamily. BTN/MOG family.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      General information above from UniProt

      Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

      Immune Checkpoint
      Immune Checkpoint Blockade: Blocking AntibodiesImmune Checkpoint Blockade: PD-L1 / B7-H1 / CD274 Blocking Antibodies
      Immune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB Antibodies
      Immune Checkpoint ProteinsPD-L1 / B7-H1 / CD274 Immune Checkpoint Proteins
      Immune Checkpoint TargetsCo-inhibitory Immune Checkpoint Targets

      PD-L1/B7-H1/CD274 대체 이름

      PD-L1/B7-H1/CD274 관련 연구

    • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
    • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
    • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
    • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
    • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.
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