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PPP2CB  Protein, Antibody, ELISA Kit, cDNA Clone

PPP2CB 관련 경로

    PPP2CB 관련 제품

    PPP2CB 관련 제품

    Featured Reagent Products

    PPP2CB 요약 및 단백질 정보

    PPP2CB 배경

    촉매 활성: A phosphoprotein + H(2)O = a protein + phosphate.
    보조 인자: Binds 1 iron ion per subunit (By similarity).
    Binds 1 manganese ion per subunit (By similarity).
    하부단위 구조: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGOL1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL.
    세포하 위치: Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
    번역 후: Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. Demethylated by PME1 (in vitro).
    Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
    염기서열 유사성: Belongs to the PPP phosphatase family. PP-1 subfamily.C
    General information above from UniProt

    PPP2CB 대체 이름

    PP2CB,PP2Abeta, [homo-sapiens]
    PP2Ac,AI115466,D8Ertd766e, [mus-musculus]

    PPP2CB 관련 연구

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