PMM2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All PMM2 reagents are produced in house and quality controlled, including 1 PMM2 Antibody, 30 PMM2 Gene, 1 PMM2 IP Kit, 1 PMM2 Protein, 1 PMM2 qPCR. All PMM2 reagents are ready to use.

PMM2 Related Research Area

PMM2 Background

Phosphomannomutase 2, also known as PMM2 and CDG1, belongs to theeukaryotic PMM family. Phosphomannomutase 2 catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mannose 1-phosphate is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. GDP-mannose can transfer its small sugar molecule called mannose to the growing oligosaccharide chain. Once the correct number of small sugar molecules are linked together to form the oligosaccharide, it can be attached to a protein. Phosphomannomutase 2 is also required for a number of critical mannosyl transfer reactions. Mutations in PMM2 gene have been shown to cause defects in the protein glycosylation pathway manifest as carbohydrate-deficient glycoprotein syndrome type I.

PMM2 References

  • Jaeken J. et al., 2002, Annual review of genomics and human genetics. 2: 129-51.
  • Matthijs G. et al., 2000, Mol Genet Metab. 68 (2): 220-6.
  • Matthijs G. et al., 1997, Nat Genet. 16 (1): 88-92.