CD6 cDNA ORF Clone, Rat, C-His tag

Cat: RG80311-CH
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CD6 cDNA ORF Clone, Rat, C-His tag General Information
Gene
Species
Rat
NCBI Ref Seq
RefSeq ORF Size
1998 bp
Description
Full length Clone DNA of Rat Cd6 molecule with C terminal His tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-His
Tag Sequence
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CD6 Background Information

T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

Full Name
CD6 molecule
References
  • Joo YS. et al., 2000, Arthritis Rheum. 43 (2): 329-35.
  • Singer NG. et al., 2002, Int Immunol. 14 (6): 585-97.
  • Gimferrer I. et al., 2005, J Immunol. 175 (3): 1406-14.
  • Alonso R. et al., 2010, J Autoimmun. 35 (4): 336-41.
  • CD6 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    CD6 cDNA ORF Clone in Cloning Vector, Rat RG80311-G
    CD6 cDNA ORF Clone, Rat, untagged RG80311-UT
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    CD6 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80311-ACGLN
    CD6 cDNA ORF Clone, Rat, C-OFPSpark® tag RG80311-ACR
    CD6 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80311-CF
    CD6 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80311-NF
    CD6 cDNA ORF Clone, Rat, N-His tag RG80311-NH
    CD6 cDNA ORF Clone, Rat, C-HA tag RG80311-CY
    CD6 cDNA ORF Clone, Rat, N-HA tag RG80311-NY
    CD6 cDNA ORF Clone, Rat, C-Myc tag RG80311-CM
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    CD6 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    CD6 cDNA ORF Clone in Cloning Vector, Mouse MG50711-G
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    CD6 cDNA ORF Clone, Mouse, C-His tag MG50711-CH
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    CD6 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CD6 cDNA ORF Clone in Cloning Vector, Human HG17051-G
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    CD6 cDNA ORF Clone, Human, C-OFPSpark® tag HG17051-ACR
    CD6 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG17051-CF
    CD6 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG17051-NF
    CD6 cDNA ORF Clone, Human, C-His tag HG17051-CH
    CD6 cDNA ORF Clone, Human, N-His tag HG17051-NH
    CD6 cDNA ORF Clone, Human, C-HA tag HG17051-CY
    CD6 cDNA ORF Clone, Human, N-HA tag HG17051-NY
    CD6 cDNA ORF Clone, Human, C-Myc tag HG17051-CM
    CD6 cDNA ORF Clone, Human, N-Myc tag HG17051-NM
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