Anti-S100A16 Antibody

Cat: 11137-R140

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Anti-S100A16 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-S100A16 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human S100A16
Immunogen
Recombinant Human S100A16 protein (Catalog#11137-HNAE)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human S100A16 (rh S100A16; Catalog#11137-HNAE; Q96FQ6; Met1-Ser103).
Source
Monoclonal Rabbit IgG Clone #140
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-S100A16 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-S100A16 Antibody Alternative Names

Anti-AAG13 Antibody;Anti-DT1P1A7 Antibody;Anti-MGC17528 Antibody;Anti-S100F Antibody

S100A16 Background Information

S100A16 is a member of S100 protein super family that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Differently from most S100 proteins, the conformational rearrangement upon calcium binding is minor. Immunoprecipitation analysis revealed that S100A16 could physically interact with tumor suppressor protein p53, also a known inhibitor of adipogenesis. Overexpression or RNA interference-initiated reduction of S100A16 led to the inhibition or activation of the expression of p53-responsive genes, respectively. S100A16 protein is a novel adipogenesis-promoting factor.

Full Name
S100 calcium binding protein A16
References
  • Sturchler E, et al. (2006) S100A16, a novel calcium-binding protein of the EF-hand superfamily. J Biol Chem. 281(50): 38905-17.
  • Liu Y, et al. (2011) Identification of S100A16 as a Novel Adipogenesis Promoting Factor in 3T3-L1 Cells. Endocrinology. 152(3): 903-11.
  • Babini E, et al. (2011) Structural characterization of human S100A16, a low-affinity calcium binder. J Biol Inorg Chem. 16(2): 243-56.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-S100A16 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 11137-RP02
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