Smad5 항체, 토끼 다클론 항체, Antigen Affinity Purified

  • Smad5 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
데이터시트리뷰관련제품프로토콜
 SMAD5 항체 제품 정보
면역원:Recombinant Mouse SMAD5 protein (Catalog#50728-M20B)
Clone ID:
면역글로불린(Ig) 유형:Rabbit IgG
농도:
내독소:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
제조방법:Produced in rabbits immunized with purified, recombinant Mouse SMAD5 (rM SMAD5; Catalog#50728-M20B; P97454; Thr2-Ser465). SMAD5 specific IgG was purified by Mouse SMAD5 affinity chromatography.
 SMAD5 Antibody IHC Application Image
Smad5 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse SMAD5 in mouse intestine with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other SMAD5 Antibody Products
Smad5 연구배경

SMAD5 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. It is also involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.

 Smad5 참고자료
  • Vinayagam A. et al., 2011, Sci Signal. 4 (189): rs8.
  • Sangadala S. et al., 2007, J Biomol Struct Dyn. 25 (1): 11-23.
  • Riggins GJ. et al., 1996, Nat Genet. 13 (3): 347-9.
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