Anti-STAT6 Antibody

Cat: 13190-RP02

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All STAT6 Reagents

Anti-STAT6 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-STAT6 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human STAT6
Recombinant Human STAT6 protein (Catalog#13190-H08B)
Produced in rabbits immunized with purified, recombinant Human STAT6 (rh STAT6; Catalog#13190-H08B; P42226-1; Met1-Trp847). STAT6 specific IgG was purified by Human STAT6 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-STAT6 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-STAT6 Antibody (Rabbit Polyclonal antibody) Images

Human STAT6 Immunohistochemistry(IHC) 3553
Immunochemical staining of human STAT6 in human malignant melanoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-STAT6 Antibody Alternative Names

Anti-D12S1644 Antibody;Anti-IL-4-STAT Antibody;Anti-STAT6B Antibody;Anti-STAT6C Antibody

STAT6 Background Information

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-?B and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggest that the direct interaction between Stat6 and NF-?B may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-?B. 

Full Name
signal transducer and activator of transcription 6, interleukin-4 induced
  • Litterst CM, et al. (2001) Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 276 (49): 45713-21.
  • Stutz AM, et al. (1999) Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 163 (8): 4383-91.
  • Yang J, et al. (2002) Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 21 (18): 4950-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-STAT6 Antibody Mouse Monoclonal FCM,ICC/IF,IF 13190-MM03
    Anti-STAT6 Antibody Mouse Monoclonal ELISA 13190-MM02
    Anti-STAT6 Antibody (FITC) Mouse Monoclonal FCM 13190-MM03-F
    Anti-STAT6 Antibody (PE) Mouse Monoclonal FCM 13190-MM03-P
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