SerpinI1 / Neuroserpin 항체, 토끼 단클론항체

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    휴먼 SerpinI1 항체 제품 정보
    면역원:Recombinant Human SerpinI1 protein (Catalog#11107-H08H)
    Clone ID:001
    면역글로불린(Ig) 유형:Rabbit IgG
    농도:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinI1 (rh SerpinI1; Catalog#11107-H08H; NP_005016.1; Met 1-Leu 410).
    Other SerpinI1 Antibody Products
    Neuroserpin/SerpinI1 연구배경

    Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein which belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons. Neuroserpin is predominantly expressed in the brain, and is expressed in the late stages of neurogenesis during the process of synapse formation. Overexpression of neuroserpin in an anterior pituitary corticotroph cell line results in the extension of neurite-like processes, suggesting that neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration. Neuroserpin may be involved in the formation or reorganization of synaptic connections, as well as synaptic plasticity in the adult nervous system. Neuroserpin may also protect neurons from cell damage by tissue-type plasminogen activator. Defects of neuroserpin are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B).

    휴먼 Neuroserpin/SerpinI1 참고자료
  • Schrimpf SP. et al., 1997, Genomics. 40 (1): 55-62.
  • Hill RM. et al., 2002, Ann N Y Acad Sci. 971: 406-15.
  • Yepes M. et al., 2004, Thromb. Haemost. 91 (3): 457-64.
  • Galliciotti G. et al., 2006, Front Biosci. 11: 33-45.
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    Cat No: 11107-R001-50
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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