TGM2 / Transglutaminase 2 항체, 토끼 단클론항체

    데이터시트리뷰관련제품프로토콜
    휴먼 TGM2 항체 제품 정보
    면역원:Recombinant Human TGM2 / Transglutaminase 2 protein (Catalog#11095-H07B)
    Clone ID:001
    면역글로불린(Ig) 유형:Rabbit IgG
    농도:
    내독소:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Human TGM2 / Transglutaminase 2 (rh TGM2 / Transglutaminase 2; Catalog#11095-H07B; NP_004604.2; Met 1-Ala 687).
    Other TGM2 Antibody Products
    TGM2 / Transglutaminase 2 연구배경

    Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.

    휴먼 TGM2 / Transglutaminase 2 참고자료
  • Ruan Q, et al. (2007) Transglutaminase 2 in neurodegenerative disorders. Front Biosci. 12: 891-904.
  • Ai L, et al. (2008) The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. Carcinogenesis. 29(3): 510-8.
  • Filiano AJ, et al. (2010) Transglutaminase 2 protects against ischemic stroke. Neurobiol Dis. 39(3): 334-43.
  • Park D, et al. (2010) Transglutaminase 2: a multi-functional protein in multiple subcellular compartments. Amino Acids. 39(3): 619-31.
  • Miyoshi N, et al. (2010) TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer. Ann Surg Oncol. 17(4): 967-72.
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