TIM-3 (Protein|Antibody|cDNA Clone|ELISA Kit)

All TIM-3 reagents are produced in house and quality controlled, including 9 TIM-3 Antibody, 2 TIM-3 ELISA, 16 TIM-3 Gene, 1 TIM-3 IPKit, 6 TIM-3 Lysate, 6 TIM-3 Protein, 1 TIM-3 qPCR. All TIM-3 reagents are ready to use.

Recombinant TIM-3 proteins are expressed by HEK293 Cells, HEK293 with fusion tags as C-His, C-human IgG1-Fc, C-human IgG1-Fc & His.

TIM-3antibodies are validated with different applications, which are ELISA, WB, IP, ELISA(Det), ELISA(Cap).

TIM-3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TIM-3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

TIM-3ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.

TIM-3 Protein (6)

Species

TIM-3 Protein, Mouse, Recombinant (Fc Tag)

51152-M02H

Expression host: HEK293 Cells

Mouse TIM-3/HAVCR2  Protein 12134

TIM-3 Protein, Cynomolgus, Recombinant (Fc Tag)

90312-C02H

Expression host: HEK293 Cells

Cynomolgus TIM-3/HAVCR2  Protein 12962

TIM-3 Protein, Human, Recombinant (His & Fc Tag)

10390-H03H

Expression host: HEK293 Cells

Human TIM-3/HAVCR2  Protein 8763

TIM-3 Protein, Human, Recombinant (His Tag)

10390-H08H

Expression host: HEK293 Cells

Human TIM-3/HAVCR2  Protein 8764

TIM-3 Protein, Mouse, Recombinant (His Tag)

51152-M08H

Expression host: HEK293 Cells

Mouse TIM-3/HAVCR2  Protein 12135
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TIM-3 Antibody (9)

Application Clonality
Host

Anti-TIM-3 Antibody

10390-MM04

Application: ELISA,ELISA(Det)

Clonality: MAb

Anti-TIM-3 Antibody

51152-RP01

Application: ELISA

Clonality: PAb

Anti-TIM-3 Antibody

10390-RP01

Application: ELISA

Clonality: PAb

Anti-TIM-3 Antibody

10390-R024

Application: ELISA,ELISA(Cap)

Clonality: MAb

Anti-TIM-3 Antibody

51152-T16

Application: ELISA

Clonality: PAb

Anti-TIM-3 Antibody

10390-RP02

Application: ELISA

Clonality: PAb

Anti-TIM-3 Antibody

10390-T16

Application: ELISA

Clonality: PAb

Anti-TIM-3 Antibody

10390-R108

Application: ELISA

Clonality: MAb

Anti-TIM-3 Antibody

51152-T52

Application: WB,ELISA,IP

Clonality: PAb

Mouse TIM-3/HAVCR2  Immunoprecipitation(IP) 6099
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TIM-3 ELISA KIT & match antibody elias pair set ( 2 )

TIM-3 ELISA Kit, Human

KIT10390

Sensitivity: 24.6 pg/mL

Human TIM-3/HAVCR2  ELISA Kit Standard Curve 61

TIM-3 Matched ELISA Antibody Pair Set,Human

SEK10390

Assay Range: 31.25 pg/ml

Human TIM-3/HAVCR2  ELISA Pair Set Standard Curve 13830

TIM-3 cDNA Clone (16)

Human
Rat
Mouse
XM_006246171.3

TIM-3 qPCR Primer (1)

TIM-3 IP Kit (1)

TIM-3 Lysate (6)

Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.

Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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Gene
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