TNF-alpha/TNFA/TNFSF2  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Human Cells  
10602-H01H-50
10602-H01H-100
10602-H01H-10
50 µg 
100 µg 
10 µg 
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발현 숙주: E. coli  
10602-HNAE-500
10602-HNAE-50
10602-HNAE-100
10602-HNAE-10
10602-HNAE-1
500 µg 
50 µg 
100 µg 
10 µg 
1 mg 
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제품 설명: Active  
발현 숙주: E. coli  
50349-MNAE-500
50349-MNAE-5
50349-MNAE-20
50349-MNAE-100
50349-MNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
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발현 숙주: E. coli  
80045-RNAE-500
80045-RNAE-5
80045-RNAE-20
80045-RNAE-100
80045-RNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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발현 숙주: E. coli  
90330-CNAE-50
90330-CNAE-100
90330-CNAE-10
50 µg 
100 µg 
10 µg 
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발현 숙주: E. coli  
90018-CNAE-500
90018-CNAE-5
90018-CNAE-20
90018-CNAE-100
90018-CNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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제품 설명: Active  
발현 숙주: E. coli  
70003-DNAE-50
70003-DNAE-5
70003-DNAE-100
70003-DNAE-10
50 µg 
5 µg 
100 µg 
10 µg 
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발현 숙주: E. coli  
60002-FNAE-5
60002-FNAE-20
60002-FNAE-10
5 µg 
20 µg 
10 µg 
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TNF-alpha/TNFA/TNFSF2 Related Area

TNF-alpha/TNFA/TNFSF2 관련 제품

TNF-alpha/TNFA/TNFSF2 요약 및 단백질 정보

TNF-alpha/TNFA/TNFSF2 배경

유전자 요약: Tumor necrosis factor (TNF) is a multifunctional proinflammatory cytokine secreted predominantly by monocytes/macrophages that has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. TNF was originally identified in mouse serum after injection with Mycobacterium bovis strain bacillus Calmette-Guerin (BCG) and endotoxin. Serum from such animals was cytotoxic or cytostatic to a number of mouse and human transformed cell lines and produced hemorrhagic necrosis and in some instances complete regression of certain transplanted tumors in mice
General information above from NCBI
하부단위 구조: Homotrimer. Interacts with SPPL2B. {ECO:0000269|PubMed:16829951}.
세포하 위치: Cell membrane {ECO:0000269|PubMed:16829952}; Single-pass type II membrane protein {ECO:0000269|PubMed:16829952}.; Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.; Tumor necrosis factor, soluble form: Secreted.; C-domain 1: Secreted.; C-domain 2: Secreted.
번역 후: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:9034191}.; The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. {ECO:0000269|PubMed:10205166, ECO:0000269|PubMed:8597870}.; O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. {ECO:0000269|PubMed:8631363}.
질병과의 관련성: DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). {ECO:0000269|PubMed:12746914}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
염기서열 유사성: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

TNF-alpha Protein & Antibody

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

TNF-alpha/TNFA/TNFSF2 대체 이름

TNF-alpha/TNFA/TNFSF2 관련 연구

  • Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5.
  • Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".