All TNFR2 reagents are produced in house and quality controlled, including 18 TNFR2 Antibody, 2 TNFR2 ELISA, 41 TNFR2 Gene, 1 TNFR2 IPKit, 7 TNFR2 Lysate, 7 TNFR2 Protein, 2 TNFR2 qPCR. All TNFR2 reagents are ready to use.
Recombinant TNFR2 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc, C-human IgG1-Fc & His.
TNFR2antibodies are validated with different applications, which are WB, ELISA, IP, FCM, Neutralization, ELISA(Det), ELISA(Cap).
TNFR2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TNFR2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
TNFR2ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Expression host: HEK293 Cells
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.