TWEAK / TNFSF12 (Protein | Antibody | cDNA Clone | ELISA Kit)

All TWEAK / TNFSF12 reagents are produced in house and quality controlled, including 65 TWEAK / TNFSF12 Gene, 4 TWEAK / TNFSF12 Lysate, 4 TWEAK / TNFSF12 Protein, 3 TWEAK / TNFSF12 qPCR. All TWEAK / TNFSF12 reagents are ready to use.

TWEAK / TNFSF12 Protein (4)

    TWEAK / TNFSF12 cDNA Clone (65)

    NM_003809.2
    NM_011614.1
    NM_001001513.2
    NM_001205135.1
    NM_001205168.1

    TWEAK / TNFSF12 Lysate (4)

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      TWEAK / TNFSF12 Background

      TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

      TWEAK / TNFSF12 References

      • Wiley SR, et al. (2004) TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 14(3-4):241-9.
      • Campbell S, et al. (2006) The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. Front Biosci. 9:2273-84.
      • Lynch CN, et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 274(13):8455-9.

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