APRIL / TNFSF13 (Protein | Antibody | cDNA Clone | ELISA Kit)

All APRIL / TNFSF13 reagents are produced in house and quality controlled, including 1 APRIL / TNFSF13 Antibody, 39 APRIL / TNFSF13 Gene, 1 APRIL / TNFSF13 Lysate, 1 APRIL / TNFSF13 Protein, 2 APRIL / TNFSF13 qPCR. All APRIL / TNFSF13 reagents are ready to use.

APRIL / TNFSF13 Background

TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF17/BCMA. TNFSF13 is lowly expressed in normal tissues, but is elevated in several types of tumors and transformed cell lines. It is mportant for B cell development. TNFSF13 may also play a role in T-independent type II antigen responses and T cell survival, and induce proliferation/survival of non lymphoid cells. It exists as a functional homotrimer. It can bind to two cell surface receptors, BCMA and TACI, which it shares with BAFF to exert downstream T- and B-cell regulatory effects. TNFSF13 also has been demonstrated to bind to proteoglycans on the cell surface.

APRIL / TNFSF13 References

  • Bossen C, et al. (2007) BAFF, APRIL and their receptors: structure, function and signaling. Semin. Immunol. 18(5):263-75.
  • Tangye SG, et al. (2007) BAFF, APRIL and human B cell disorders. Immunol. 18(5): 305-17.
  • Osman W, et al. (2012) Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. PLoS One. 7(4):e32683.