TRAIL R1/CD261/TNFRSF10A  Protein, Antibody, ELISA Kit, cDNA Clone

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발현 숙주: Human Cells  
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TRAIL R1/CD261/TNFRSF10A 관련 경로

TRAIL R1/CD261/TNFRSF10A 관련 제품

TRAIL R1/CD261/TNFRSF10A 요약 및 단백질 정보

TRAIL R1/CD261/TNFRSF10A 배경

유전자 요약: The TRAIL R1 protein encoded by this TNFRSF10A gene is a member of the TNF-receptor superfamily. TRAIL R1 is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by TRAIL R1.
General information above from NCBI
하부단위 구조: Can interact with TRADD and RIPK1. Interacts with ARAP1.
세포하 위치: Membrane; Single-pass type I membrane protein.
조직 특이성: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
염기서열 유사성: Contains 1 death domain.
Contains 3 TNFR-Cys repeats.C
General information above from UniProt

Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

TRAIL R1/CD261/TNFRSF10A 대체 이름

TRAIL R1/CD261/TNFRSF10A 관련 연구

  • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
  • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.
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