Transferrin Receptor / TFRC (Protein | Antibody | cDNA Clone | ELISA Kit)

All Transferrin Receptor / TFRC reagents are produced in house and quality controlled, including 27 Transferrin Receptor / TFRC Antibody, 54 Transferrin Receptor / TFRC Gene, 3 Transferrin Receptor / TFRC IP Kit, 4 Transferrin Receptor / TFRC Lysate, 5 Transferrin Receptor / TFRC Protein, 3 Transferrin Receptor / TFRC qPCR. All Transferrin Receptor / TFRC reagents are ready to use.

All Transferrin Receptor / TFRC Reagents

Transferrin Receptor / TFRC Background

Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

Transferrin Receptor / TFRC References

  • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
  • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
  • Tosoni D., et al., 2005, Cell 123:875-888.
  • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.