VCAM1/VCAM-1/CD106  Protein, Antibody, ELISA Kit, cDNA Clone

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VCAM1/VCAM-1/CD106 Related Area

VCAM1/VCAM-1/CD106 관련 경로

    VCAM1/VCAM-1/CD106 요약 및 단백질 정보

    VCAM1/VCAM-1/CD106 배경

    유전자 요약: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
    General information above from NCBI
    하부단위 구조: Binds to ECMV-D capsid proteins and acts as a receptor for this virus. {ECO:0000250}.
    도메인: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
    세포하 위치: Membrane; Single-pass type I membrane protein.
    조직 특이성: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
    유도: By cytokines (e.g. IL-1, TNF-alpha).
    번역 후: Sialoglycoprotein.
    염기서열 유사성: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    VCAM1/VCAM-1/CD106 대체 이름

    CD106,INCAM-100, [homo-sapiens]
    CD106,DKFZp779G2333,INCAM-100,MGC99561,VCAM1,VCAM-1, [human]
    CD106,VCAM1,VCAM-1, [mouse]
    CD106,Vcam-1, [mus-musculus]

    VCAM1/VCAM-1/CD106 관련 연구

  • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
  • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.
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