VEGFR2 / Flk-1 / CD309 / KDR 항체, 토끼 다클론 항체, Antigen Affinity Purified

데이터시트리뷰관련제품프로토콜
 KDR 항체 제품 정보
면역원:Recombinant Rat VEGFR2 / Flk-1 / CD309 / KDR protein (Catalog#80113-R08H)
Clone ID:
면역글로불린(Ig) 유형:Rabbit IgG
농도:
내독소:
Formulation:0.2 μm filtered solution in PBS
제조방법:Produced in rabbits immunized with purified, recombinant Rat VEGFR2 / Flk-1 / CD309 / KDR (rh VEGFR2 / Flk-1 / CD309 / KDR; Catalog#80113-R08H; EDM04022.1; Met1-Glu760). VEGFR2 / Flk-1 / CD309 / KDR specific IgG was purified by Rat VEGFR2 / Flk-1 / CD309 / KDR affinity chromatography.
Other KDR Antibody Products
VEGFR2/KDR/Flk-1/CD309 연구배경

VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 VEGFR2/KDR/Flk-1/CD309 참고자료
  • Shibuya M. (2006) Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E. Endothelium. 13(2): 63-9.
  • Marwick JA, et al. (2010) Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. J Inflamm (Lond). 7(1): 11.
  • Bruns AF, et al. (2010) Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic. 11(1): 161-74.
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    Cat No: 80113-T16-200
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