Anti-SIRP alpha Antibody (APC) (Rabbit Monoclonal antibody) General Information
Anti-SIRP alpha Antibody (APC)
Reacts with: Mouse
Mouse SIRP alpha
Recombinant Mouse SIRP alpha/SIRPA Protein (Catalog#50956-M08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIRP alpha/SIRPA (rM SIRP alpha/SIRPA; Catalog#50956-M08H; BAA20376.1; Met1-Asn373) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Monoclonal Rabbit IgG Clone #012
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
5 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !
Flow cytometric analysis of Mouse SIRPA(CD172a) expression on BABL/c bone marrow cells. Cells were stained with APC-conjugated anti-Mouse SIRPA(CD172a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
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