Anti-TNFR2 / TNFRSF1B Antibody (HRP)

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Anti-TNFR2 / TNFRSF1B Antibody (HRP) (Rabbit Monoclonal antibody) General Information

Product name
Anti-TNFR2 / TNFRSF1B Antibody (HRP)
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse TNFR2 / TNFRSF1B
Immunogen
Recombinant Mouse TNFR2 / TNFRSF1B / CD120b Protein (Catalog#50128-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TNFR2 / TNFRSF1B / CD120b (rM TNFR2 / TNFRSF1B / CD120b; Catalog#50128-M08H; NP_035740.2; Met1-Gly258), and conjugated with horseradish-peroxidase (HRP).
Source
Monoclonal Rabbit IgG Clone #340
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
HRP
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TNFR2 / TNFRSF1B Antibody (HRP) (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 0.1-1 μg/ml
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TNFR2 / TNFRSF1B Antibody (HRP): Alternative Names

Anti-CD120b Antibody; Anti-p75 Antibody; Anti-TNF-alphaR2 Antibody; Anti-TNF-R-II Antibody; Anti-TNF-R2 Antibody; Anti-TNF-R75 Antibody; Anti-TNFalpha-R2 Antibody; Anti-TNFBR Antibody; Anti-Tnfr-1 Antibody; Anti-Tnfr2 Antibody; Anti-TNFR80 Antibody; Anti-TNFRII Antibody

TNFR2 / TNFRSF1B Background Information

Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD12b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD12b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD12b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD12b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Full Name
tumor necrosis factor receptor superfamily, member 1b
References
  • Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
  • Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
  • Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
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