S100A1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All S100A1 reagents are produced in house and quality controlled, including 6 S100A1 Antibody, 1 S100A1 ELISA, 30 S100A1 Gene, 1 S100A1 Lysate, 3 S100A1 Protein, 2 S100A1 qPCR. All S100A1 reagents are ready to use.

S100A1 Protein (3)

    S100A1 Antibody (6)

      S100A1 ELISA Kit & Match Antibody ELISA Pair Set (1)

      S100A1 cDNA Clone (30)

      S100A1 Lysate (1)

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        S100A1 Background

        S1A1 is a Ca2+binding protein of the EF-hand type that belongs to the S1 protein family. S1 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S1A1, and recently, S1A1 is also identified as a potent molecular chaperone and a new member of the Hsp7/Hsp9 multichaperone complex. S1A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S1A1 gene have been implicated in cardiomyopathies.

        S100A1 References

        • Remppis, A .et al., 1996, Biochim. Biophs. Acta. 1313: 253-257.
        • Most, P. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 13889-13894
        • Okada, M. et al., 2004, J. Biol. Chem. 279: 4221-4233.
        • Schafer, W.E. et al., 1995, Genomics. 25: 638-643.
        • Landar, A. et al., 1996, Cell. Calcium. 20: 279-285.

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