Anti-CNTF Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Mouse
Recombinant Mouse CNTF / Ciliary Neurotrophic Factor Protein (Catalog#51181-M07E)
Produced in rabbits immunized with purified, recombinant Mouse CNTF / Ciliary Neurotrophic Factor (rM CNTF / Ciliary Neurotrophic Factor; Catalog#51181-M07E; NP_740756.1; Ala2-Met198). CNTF / Ciliary Neurotrophic Factor specific IgG was purified by Mouse CNTF / Ciliary Neurotrophic Factor affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunochemical staining of mouse CNTF in mouse brain with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
Anti-CNTF Antibody: Alternative Names
CNTF Background Information
Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic factor (CNTF) has biological effects through the activation of a multi- subunit receptor complex, consisting of an extracelluar CNTF binding subunit (CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp13 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocyteands may be relevant in reducing tissue destruction during inflammatory attacks. CNTF also is a survival factor for neurons of the peripheral sensory sympathetic and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.
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