TSPAN1 항체, 토끼 다클론항체

데이터시트리뷰프로토콜
발현 숙주: Human Cells  
  • Slide 1
13073-H07H-20
13073-H07H-100
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
13073-H04H-20
13073-H04H-100
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
13073-H15H-20
13073-H15H-100
20 µg 
100 µg 
Add to Cart

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TSPAN1 antibody 연구배경

TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-80 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone; in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.

휴먼 TSPAN1 antibody 참고자료
  • Chen L. et al., 2010, J Korean Med Sci. 25 (10): 1438-42.
  • Chen L. et al., 2010, Tumori. 96 (5): 744-50.
  • Nabokina SM. et al., 2011, Am J Physiol Gastrointest Liver Physiol. 301 (5): G808-13.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".