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에볼라 바이러스 EBOV (subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Glycoprotein / GP1 단백질 (His 태그)

데이터시트리뷰프로토콜
반응성: EBOV  
신청: ELISA  WB  IHC-P  IP  
  • Slide 1
40304-T60-50
40304-T60-100
50 µg 
100 µg 
Add to Cart
반응성: EBOV  
신청: ELISA  IHC-P  FCM  IF  IP  ICC/IF  
    40304-RP01-200
    40304-RP01-100
    200 µg 
    100 µg 
    Add to Cart
    반응성: EBOV  
    신청: 
    • Slide 1
    40368-MM07-50
    40368-MM07-100
    50 µg 
    100 µg 
    Add to Cart
    반응성: EBOV  
    신청: ELISA  WB  IHC-P  FCM  IF  IHC-Fr  ICC/IF  
      40094-R106-50
      40094-R106-100
      50 µg 
      100 µg 
      Add to Cart
      반응성: EBOV  
      신청: ELISA  IHC-P  FCM  IF  IHC-Fr  ICC/IF  
        40094-R301-50
        40094-R301-100
        50 µg 
        100 µg 
        Add to Cart
        반응성: EBOV  
        신청: ELISA  IHC-P  FCM  IF  ICC/IF  
          40442-MM02-50
          40442-MM02-100
          50 µg 
          100 µg 
          Add to Cart
          반응성: EBOV  
          신청: ELISA  IHC-P  FCM  IF  ICC/IF  
            40442-MM28-50
            40442-MM28-100
            50 µg 
            100 µg 
            Add to Cart
            반응성: EBOV  
            신청: ELISA  WB  IHC-P  IP  
            • Slide 1
            40368-T60-50
            40368-T60-100
            50 µg 
            100 µg 
            Add to Cart
            반응성: EBOV  
            신청: ELISA  IHC-P  FCM  IF  IP  ICC/IF  
              40442-RP01-200
              40442-RP01-100
              200 µg 
              100 µg 
              Add to Cart
              반응성: EBOV  
              신청: ELISA  FCM  IF  IP  ICC/IF  
                40094-RP01-200
                40094-RP01-100
                200 µg 
                100 µg 
                Add to Cart
                반응성: EBOV  
                신청: WB  IHC-P  IP  
                • Slide 1
                40094-T44-50
                40094-T44-100
                50 µg 
                100 µg 
                Add to Cart
                40094-V08H2L-300 
                40304-V08B1L-300 
                40304-VCCH1L-300 
                40304-V02H1L-300 
                40094-V08B2L-300 
                40442-V02HL-300 
                40304-V08HL-300 
                40442-V08B1L-300 
                40442-V08H1L-300 
                40442-V08HL-300 
                40442-V08H2L-300 
                40442-V08BL-300 
                40442-V04HL-300 
                40094-V02H1L-300 
                40368-V08BL-300 
                40094-V08H1L-300 
                40368-V02HL-300 
                40368-V02H1L-300 
                40459-V08HL-300 
                40459-V08H1L-300 
                40442-V08H4L-300 

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                EBOV-G/Ebola Glycoprotein protein 연구배경

                The fourth gene of the EBOV genome encodes a 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD); the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry; the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.

                EBOV EBOV-G/Ebola Glycoprotein protein 참고자료
                1. Volchkov VE, et al. Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5762-7.
                2. Lee JE, et al. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 2008 Jul 10;454(7201):177-82. doi: 10.1038/nature07082.
                3. Hood CL, et al. Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity. J Virol. 2010 Mar;84(6):2972-82. doi: 10.1128/JVI.02151-09.
                4. Cook JD and Lee JE. The secret life of viral entry glycoproteins: moonlighting in immune evasion. PLoS Pathog. 2013 May;9(5):e1003258. doi: 10.1371/journal.ppat.1003258.
                5. Miller EH and Chandran K. Filovirus entry into cells - new insights. Curr Opin Virol. 2012 Apr;2(2):206-14. doi: 10.1016/j.coviro.2012.02.015.
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